Calcineurin, myocardial hypertrophy, and electrical remodeling
نویسندگان
چکیده
منابع مشابه
Electrical remodeling in pressure-overload cardiac hypertrophy: role of calcineurin.
BACKGROUND Myocyte hypertrophy accompanies many forms of heart disease, but its contribution to electrical remodeling is unknown. METHODS AND RESULTS We studied mouse hearts subjected to pressure overload by surgical thoracic aortic banding. In unbanded control hearts, action potential duration (APD) was significantly longer in subendocardial myocytes compared with subepicardial myocytes. Hyp...
متن کاملEditorial C alcineurin , myocardial hypertrophy , and electrical remodeling
See article by Dong et al. [7] (pages 320 –332) in this sion of calcineurin in mice has been previously shown to issue. lead to extensive CVH, heart failure, and sudden death [6]. In the present issue of the Journal, Dong et al. [7] present The pathogenesis of cardiac ventricular hypertrophy new experimental data that shed some new light on the (CVH), both compensated and that associated with c...
متن کاملThe Cardiac CaMKII Genes and Contribute Redundantly to Adverse Remodeling but Inhibit Calcineurin-Induced Myocardial Hypertrophy
Research Unit Cardiac Epigenetics, Dept of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/ Mannheim, Germany; Dept of Cardiology, Saarland University, Homburg, Germany; Dept of Internal Medicine II, University of Regensburg, Regensburg, Germany; British Heart Foundation Centre of Research Excellence, National ...
متن کاملCalcineurin signalling mechanisms in myocardial hypertrophy
Calcineurin dephosphorylates multiple serine residues near the N terminus of NFAT proteins enabling them to translocate from cytoplasm to nucleus, where they activate a subset of hypertrophic response genes. Transgenic mice over-expressing a constitutively active form of calcineurin or NFAT3, developed obviously hypertrophy and heart failure or sudden death proving its pathogenic role. Here we ...
متن کاملSignaling in myocardial hypertrophy: life after calcineurin?
Signaling in Myocardial Hypertrophy : Life After Calcineurin? Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.84.6.633 1999;84:633-646 Circ Res. http://circres.ahajournals.org/content/84/6/633 World...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2003
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(02)00835-0